Tuesday, August 19, 2014

How Radioimmunoconjugates are Used

Radioimmunoconjugates (radiolabeled antibodies and radiolabeled proteins) are a class of conjugates used primarily for cancer/tumor imaging and therapy.  They consist of either a targeting antibody / protein directly labeled with a radionuclide (radioisotope) such as iodine 131, or a targeting antibody / protein conjugated to a radionuclide chelator (e.g., CHX-A, DOTA) and then indirectly labeled with a radionuclide, e.g., indium 111 or yttrium 90 via the chelator.  Radioimmunoconjugates offer radio-immunodiagnostic solutions at low doses of radionuclide, but can also provide radioimmunotherapy at high doses of the radionuclide.Example of FDA approved radioimmunoconjugates include Zevalin® and Bexxar..