Goodwin Biotechnology-- Your Single Source Solution™ for Cytotoxic ADCs

Together with our collaborative partner, Coldstream Labs, GoodwinBiotechnology has the experience, expertise, and capability to develop and manufacture highly potent CADCs from proof of concept through to non-clinical and clinical use, late stage as well as commercial manufacturing.

Goodwin Biotechnology is a full-service, customer-focused and integrated contract services provider with a pioneering focus on the development and manufacturing of Cytotoxic Antibody Drug Conjugates (CADCs) from cell line development or exploratory proof-of-concept through process development, scale up,  and cGMP manufacturing. 

Goodwin Biotechnology Global Customer Value Leadership Award for Mammalian Biologics Contract Manufacturing

Frost & Sullivan Presents

Goodwin Biotechnology with the Global Customer Value Leadership Award for Mammalian Biologics Contract Manufacturing

Goodwin Biotechnology pioneered best-in-class practices for the development of complex Biopharmaceuticals and Antibody Drug Conjugates (ADCs)

LONDON — September 2, 2014 — Based on its recent analysis of the mammalian contract manufacturing services market, Frost & Sullivan recognises Goodwin Biotechnology with the 2014 Global Frost & Sullivan Award for Customer Value Leadership. Goodwin Biotechnology’s reputation as one of the most trusted providers of mammalian contract manufacturing and development services has been built on more than 20 years of experience in the bioprocess development and cGMP manufacturing of mammalian cell culture-derived monoclonal antibodies (mAbs), vaccines, and recombinant proteins, and more than 10 years pioneering the field of bioconjugation.

The Highest Quality Process Development

Goodwin Biotechnology will develop a robust and reproducible cell culture process development for the production of complex therapeutic protein drug candidates. Goodwin Biotechnology has experience with a number of cell cultivation technologies including stationary culture disposable flasks, spinners, WAVE disposable and stirred tank bioreactors. Goodwin Biotechnology offers cell culture production services for non-bioreactor projects.

How Radioimmunoconjugates are Used

Radioimmunoconjugates (radiolabeled antibodies and radiolabeled proteins) are a class of conjugates used primarily for cancer/tumor imaging and therapy.  They consist of either a targeting antibody / protein directly labeled with a radionuclide (radioisotope) such as iodine 131, or a targeting antibody / protein conjugated to a radionuclide chelator (e.g., CHX-A, DOTA) and then indirectly labeled with a radionuclide, e.g., indium 111 or yttrium 90 via the chelator.  Radioimmunoconjugates offer radio-immunodiagnostic solutions at low doses of radionuclide, but can also provide radioimmunotherapy at high doses of the radionuclide.Example of FDA approved radioimmunoconjugates include Zevalin^® and Bexxar..

Goodwin Biotechnology offers a full range of mammalian cell culture services

Goodwin Biotechnology offers a full range of mammalian cell culture services ranging from the creation of up and downstream processes sufficient for the manufacturing of proof of concept, toxicology product material and processes for licensed manufacturing. 

Understand the Cell Line Development Process

Cell line development is important in the manufacturing of high quality recombinant proteins. Goodwin Biotechnology has extensive experience in this field. In conjunction with its collaborative partners, Goodwin Biotechnology can develop a variety of high expressing cell lines from cDNA provided by the client
that can routinely produce up to 4g/L

Goodwin Biotechnology offers full range of cell culture services

Goodwin Biotechnology offers a full range of mammalian cell culture services ranging from the creation of up and downstream processes sufficient for the manufacturing of proof of concept, toxicology product material and processes for licensed manufacturing.

We work with most cell lines used for manufacturing, including CHO, NS/0, BHK, 293 as well as murine hybridomas, and all selection systems used with these lines. We also work with several different selection systems such as dhfr - /methotrexate CHO, mycophenolic acid/xanthine, and G418 systems. Our experience includes surface dependent as well as suspension culture types.

Our Cell Line Development Process

Goodwin Biotechnology offers a Single Source Solution™ that starts with cellline development and extends through Process Development and cGMP manufacturing.

We have collaborative partners for molecular biology and cell line development activities with whom we work to develop your cell line. Working with our partners, we can develop cell lines from cDNA or gene sequences that you provide for antibodies, hybridomas, or recombination proteins and to engineer highly productive and stable cell lines in HEK-293, BHK, CHO, NS0, SP2/0 cells or proprietary third-party systems like PER.C6®, ACE, GS, and UCOE. 

Comprehensive Bioconjugation Solutions

There have been advances in the field of biologics that enable scientists to synthetically modify recombinant proteins and monoclonal antibodies and use them in therapeutics, diagnostics and other fields. Thanks to bioconjugation, these biomolecules can be used to reveal enzyme function, to track cellular events, to determine protein biodistribution, to image specific biomarkers, and to deliver drugs to specific cells. 

An Overview of Our Cell Culture Manufacturing Service

Goodwin Biotechnology offers a full range of mammalian cell culture services ranging from cell line development, with our partners, through the creation of up and downstream processes sufficient for the manufacturing of proof of concept, toxicology product material and processes for licensed cGMP manufacturing.

Cell Culture, Bioreactors and Your Opinion!

So...quick question!

Are you using a single use or stainless steel bioreactor?

A Perspective on Goodwin Biotechnology

In my five years as a member of the Goodwin family, two as a manufacturing scientist and 3 as Downstream Operations Manager, the most important thing over the years has been the “can do” attitude of the entire team. From QA, QC, Process Development to Manufacturing, we continually step up to do what’s needed to complete a client’s project. Goodwin is a great place to start out a career as we continually reinforce good manufacturing process from start to finish and it shows!